diff --git a/python/ray/tests/test_basic.py b/python/ray/tests/test_basic.py
index 1fd920dac..e19927c3f 100644
--- a/python/ray/tests/test_basic.py
+++ b/python/ray/tests/test_basic.py
@@ -507,7 +507,7 @@ def test_put_get(shutdown_only):
         assert value_before == value_after
 
 
-def test_custom_serializers(ray_start_regular):
+def custom_serializers():
     class Foo(object):
         def __init__(self):
             self.x = 3
@@ -537,6 +537,30 @@ def test_custom_serializers(ray_start_regular):
     assert ray.get(f.remote()) == ((3, "string1", Bar.__name__), "string2")
 
 
+def test_custom_serializers(ray_start_regular):
+    custom_serializers()
+
+
+def test_custom_serializers_with_pickle(shutdown_only):
+    ray.init(use_pickle=True)
+    custom_serializers()
+
+    class Foo(object):
+        def __init__(self):
+            self.x = 4
+
+    # Test the pickle serialization backend without serializer.
+    # NOTE: 'use_pickle' here is different from 'use_pickle' in
+    # ray.init
+    ray.register_custom_serializer(Foo, use_pickle=True)
+
+    @ray.remote
+    def f():
+        return Foo()
+
+    assert type(ray.get(f.remote())) == Foo
+
+
 def test_serialization_final_fallback(ray_start_regular):
     pytest.importorskip("catboost")
     # This test will only run when "catboost" is installed.
diff --git a/python/ray/worker.py b/python/ray/worker.py
index 083bd9aa1..ef35798aa 100644
--- a/python/ray/worker.py
+++ b/python/ray/worker.py
@@ -2090,6 +2090,10 @@ def _register_custom_serializer(cls,
         "Exactly one of use_pickle, use_dict, or serializer/deserializer must "
         "be specified.")
 
+    if worker.use_pickle and serializer is None:
+        # In this case it should do nothing.
+        return
+
     if use_dict:
         # Raise an exception if cls cannot be serialized efficiently by Ray.
         serialization.check_serializable(cls)