diff --git a/DEPENDS.txt b/DEPENDS.txt
index e5c10521..aa3cd021 100644
--- a/DEPENDS.txt
+++ b/DEPENDS.txt
@@ -16,7 +16,6 @@ Runtime requirements
 * `NetworkX <https://networkx.github.io>`__
 * `Pillow <https://pypi.python.org/pypi/Pillow>`__
    (or `PIL <http://www.pythonware.com/products/pil/>`__)
-* `Tifffile <https://pypi.python.org/pypi/tifffile>`__
 
 Known build errors
 ------------------
diff --git a/requirements.txt b/requirements.txt
index 7ce05c95..98f3b77f 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -5,4 +5,3 @@ scipy>=0.9
 six>=1.3
 networkx>=1.8
 pillow>=1.1.7
-tifffile>=0.2